MacrophageFramework - Multidimensional Macrophage Profiling

Provides a multidimensional computational framework for macrophage profiling based on an ontology of biological programs. The framework independently detects macrophage populations and characterizes their lineage-associated and functional-state programs using program-level expression scores, detection coverage, gene-program coherence, cluster profiles, and profile similarity. The framework is designed to capture continuous and combinatorial macrophage states without imposing binary activation categories.